{"id":144,"date":"2026-09-24T09:26:33","date_gmt":"2026-09-24T09:26:33","guid":{"rendered":"https:\/\/chronichandeczema.ca\/fr-ca\/?page_id=144"},"modified":"2026-10-03T12:34:07","modified_gmt":"2026-10-03T12:34:07","slug":"diagnosis","status":"publish","type":"page","link":"https:\/\/chronichandeczema.ca\/en-ca\/diagnosis\/","title":{"rendered":"CHE Diagnosis"},"content":{"rendered":"\n<div class=\"wp-block-group alignfull has-primary-background-color has-background has-global-padding is-layout-constrained wp-container-core-group-is-layout-79a3a007 wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--0);padding-right:var(--wp--preset--spacing--0);padding-bottom:var(--wp--preset--spacing--0);padding-left:var(--wp--preset--spacing--0)\">\n<div class=\"wp-block-cover alignfull is-light is-style-no-min-height vertical-placement-bottom horizontal-alignment-left background-opacity-50\" style=\"--disclaimer--background--color: #171438; --disclaimer--text--color: #ffffff\"><video class=\"wp-block-cover__video-background intrinsic-ignore\" autoplay muted playsinline src=\"https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/10\/hand_eczema_cinemagraph_david.mp4\" poster=\"https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/10\/talkche_diagnosis_poster_notype.jpg\" data-object-fit=\"cover\"><\/video><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim-0 has-background-dim\"><\/span><div class=\"wp-block-cover__inner-container has-global-padding is-layout-constrained wp-block-cover-is-layout-constrained\"><div class=\"cover-content-wrapper\">\n<figure class=\"wp-block-image alignfull size-full wp-block-hidden-mobile wp-block-hidden-tablet\"><picture><source media=\"(max-width: 782px)\" srcset=\"https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/imgi_3_talkche_diagnosingche_mobile.png\"><img loading=\"lazy\" decoding=\"async\" width=\"1920\" height=\"1080\" fetchpriority=\"auto\" src=\"https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/diagnosis_letterforms-1.png\" alt=\"\" class=\"wp-image-342\" srcset=\"https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/diagnosis_letterforms-1.png 1920w, https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/diagnosis_letterforms-1.png?resize=300,169 300w, https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/diagnosis_letterforms-1.png?resize=768,432 768w, https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/diagnosis_letterforms-1.png?resize=1024,576 1024w, https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/diagnosis_letterforms-1.png?resize=1536,864 1536w, https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/diagnosis_letterforms-1.png?resize=1200,675 1200w, https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/diagnosis_letterforms-1.png?resize=400,225 400w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\" \/><\/source><\/picture><\/figure>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/div><div class=\"caption\">Actor portrayal. For illustrative purposes only.<\/div><\/div>\n\n\n\n<\/div>\n\n\n\n<figure class=\"wp-block-image alignfull size-large\" style=\"margin-top:var(--wp--preset--spacing--0);margin-bottom:var(--wp--preset--spacing--0)\"><img loading=\"lazy\" decoding=\"async\" height=\"71\" width=\"1024\" src=\"https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/imgi_51_block1-gradient.jpg?w=1024\" alt=\"\" class=\"wp-image-23\" srcset=\"https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/imgi_51_block1-gradient.jpg 2880w, https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/imgi_51_block1-gradient.jpg?resize=300,21 300w, https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/imgi_51_block1-gradient.jpg?resize=768,53 768w, https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/imgi_51_block1-gradient.jpg?resize=1024,71 1024w, https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/imgi_51_block1-gradient.jpg?resize=1536,107 1536w, https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/imgi_51_block1-gradient.jpg?resize=2048,142 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<div class=\"wp-block-group alignfull has-primary-background-color has-background has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"margin-top:var(--wp--preset--spacing--0);margin-bottom:var(--wp--preset--spacing--0)\">\n<h2 class=\"wp-block-heading has-text-align-center has-secondary-color has-text-color has-link-color wp-elements-1\">THE CHALLENGE OF DIAGNOSING CHE<\/h2>\n\n\n\n<p class=\"has-text-align-center has-white-color has-text-color has-link-color wp-elements-2 wp-block-paragraph\">Patients with chronic hand eczema (CHE) may present with <strong>multiple subtypes<\/strong> and each subtype has unique immune signatures<sup>1,2<\/sup><\/p>\n\n\n\n<p class=\"has-text-align-center has-white-color has-text-color has-link-color wp-elements-3 wp-block-paragraph\">CHE is not just atopic dermatitis (AD) of the hands<sup>2<\/sup><\/p>\n\n\n\n<figure class=\"wp-block-image alignwide size-full vertical-placement-below horizontal-alignment-center background-opacity-none\"><img loading=\"lazy\" decoding=\"async\" width=\"2048\" height=\"1053\" src=\"https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/venn-diagram.jpg\" alt=\"\" class=\"wp-image-330\" srcset=\"https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/venn-diagram.jpg 2048w, https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/venn-diagram.jpg?resize=300,154 300w, https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/venn-diagram.jpg?resize=768,395 768w, https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/venn-diagram.jpg?resize=1024,527 1024w, https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/venn-diagram.jpg?resize=1536,790 1536w\" sizes=\"auto, (max-width: 2048px) 100vw, 2048px\" \/><figcaption class=\"wp-element-caption\"><mark style=\"background-color:#1a1d3c\" class=\"has-inline-color has-white-color\"><sup>a<\/sup>Percentages are from a CHE patient registry of 1163 patients across 95 centers in Germany.<sup>1<\/sup><\/mark><\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-center has-secondary-color has-text-color has-link-color wp-elements-4\">CHE SUBTYPES<\/h2>\n\n\n\n<p class=\"has-text-align-center has-white-color has-text-color has-link-color wp-elements-5 wp-block-paragraph\">Chronic hand eczema is often multifactorial, and the relationship between clinical patterns and etiological diagnoses is not a simple one.<br>Mixed forms of subtypes may exist in which more than one etiological and morphological subtype are present. Additionally, there is no reliable correlation between morphology and etiology; etiology cannot be diagnosed based solely on the appearance of hands.<sup>4,5<\/sup><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull has-white-color has-primary-background-color has-text-color has-background has-link-color wp-elements-6 has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"margin-top:var(--wp--preset--spacing--0);margin-bottom:var(--wp--preset--spacing--0);padding-top:var(--wp--preset--spacing--0);padding-bottom:var(--wp--preset--spacing--0)\">\n<div class=\"wp-block-cover alignfull has-custom-content-position is-position-center-right is-style-plain\" style=\"margin-top:var(--wp--preset--spacing--0);margin-bottom:var(--wp--preset--spacing--0);min-height:80vh;aspect-ratio:unset;\"><img loading=\"lazy\" decoding=\"async\" width=\"1440\" height=\"412\" class=\"wp-block-cover__image-background wp-image-168 size-full\" alt=\"\" src=\"https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/imgi_18_straighttalk_che_icons_bg.jpg\" data-object-fit=\"cover\" srcset=\"https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/imgi_18_straighttalk_che_icons_bg.jpg 1440w, https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/imgi_18_straighttalk_che_icons_bg.jpg?resize=300,86 300w, https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/imgi_18_straighttalk_che_icons_bg.jpg?resize=768,220 768w, https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/imgi_18_straighttalk_che_icons_bg.jpg?resize=1024,293 1024w\" sizes=\"auto, (max-width: 1440px) 100vw, 1440px\" \/><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim-0 has-background-dim\" style=\"background-color:#1b1d3e\"><\/span><div class=\"wp-block-cover__inner-container has-global-padding is-layout-constrained wp-block-cover-is-layout-constrained\"><div class=\"cover-content-wrapper\">\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-b68c6776 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-left:var(--wp--preset--spacing--lg);flex-basis:50%\">\n<p class=\"wp-block-paragraph\"><strong><strong>ETIOLOGICAL SUBTYPES INCLUDE<sup>4<\/sup><\/strong><\/strong><\/p>\n\n\n\n<p class=\"has-secondary-color has-text-color has-link-color wp-elements-7 wp-block-paragraph\"><strong>IRRITANT CONTACT DERMATITIS (ICD)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Prolonged, repeated irritant exposure (e.g., detergents)<\/li>\n\n\n\n<li>No relevant contact allergen identified<\/li>\n<\/ul>\n\n\n\n<p class=\"has-secondary-color has-text-color has-link-color wp-elements-8 wp-block-paragraph\"><strong>ATOPIC DERMATITIS (AD)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Typically, a medical history of atopic dermatitis<\/li>\n\n\n\n<li>Predisposes patients to develop ICD<\/li>\n\n\n\n<li>May have AD elsewhere<\/li>\n<\/ul>\n\n\n\n<p class=\"has-secondary-color has-text-color has-link-color wp-elements-9 wp-block-paragraph\"><strong>ALLERGIC CONTACT DERMATITIS (ACD)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Hand eczema caused by relevanta contact allergens (e.g., metals, fragrances)<\/li>\n\n\n\n<li>Identified by a positive patch test<\/li>\n<\/ul>\n\n\n\n<p class=\"has-secondary-color has-text-color has-link-color wp-elements-10 wp-block-paragraph\"><strong>PROTEIN CONTACT DERMATITIS<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Hand eczema in patients chronically exposed to proteinsb (e.g., latex, animal hair)<\/li>\n\n\n\n<li>Identified by a positive prick test<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-left:var(--wp--preset--spacing--lg);flex-basis:50%\">\n<p class=\"wp-block-paragraph\"><strong><strong>MORPHOLOGICAL SUBTYPES INCLUDE<sup>4<\/sup><\/strong><\/strong><\/p>\n\n\n\n<p class=\"has-secondary-color has-text-color has-link-color wp-elements-11 wp-block-paragraph\"><strong>HYPERKERATOTIC HAND ECZEMA<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Typically palmar<\/li>\n\n\n\n<li>More common in men<\/li>\n\n\n\n<li>Associated with tobacco smoking<\/li>\n<\/ul>\n\n\n\n<p class=\"has-secondary-color has-text-color has-link-color wp-elements-12 wp-block-paragraph\"><strong>ACUTE, RECURRENT VESICULAR HAND ECZEMA<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Typically, palmar\/fingers<\/li>\n\n\n\n<li>Intensely pruritic<\/li>\n\n\n\n<li>Associated with different etiologies<\/li>\n<\/ul>\n\n\n\n<p class=\"has-secondary-color has-text-color has-link-color wp-elements-13 wp-block-paragraph\"><strong>NUMMULAR HAND ECZEMA<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Typically on the dorsal hands<\/li>\n\n\n\n<li>Coin-shaped lesions<\/li>\n\n\n\n<li>Often associated with allergic dermatitis<\/li>\n<\/ul>\n\n\n\n<p class=\"has-secondary-color has-text-color has-link-color wp-elements-14 wp-block-paragraph\"><strong>PULPITIS<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Found on the fingertips<\/li>\n\n\n\n<li>Often caused by irritants, but may be related to atopic dermatitis or ACD<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div><\/div><\/div>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull has-white-color has-primary-background-color has-text-color has-background has-link-color wp-elements-15 has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"margin-top:var(--wp--preset--spacing--0);margin-bottom:var(--wp--preset--spacing--0)\">\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><small><sup>a<\/sup>Relevant means that there is a current exposure of the hands to the allergen, <sup>b<\/sup>food, latex, and any other biologic material.<sup>4<\/sup><\/small><\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><strong>More than 50% of patients with chronic hand eczema can have more than 1 additional diagnosed subtype.<sup>6<\/sup><\/strong><br><br><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-align-center has-secondary-color has-text-color has-link-color wp-elements-16\">CHE PATHOPHYSIOLOGY<\/h2>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-cover alignfull is-style-plain\" style=\"margin-top:var(--wp--preset--spacing--0);margin-bottom:var(--wp--preset--spacing--0);min-height:356px;aspect-ratio:unset;\"><img decoding=\"async\" class=\"wp-block-cover__image-background wp-image-410 size-large\" alt=\"\" src=\"https:\/\/chronichandeczema.ca\/fr-ca\/wp-content\/uploads\/sites\/49\/2026\/09\/straighttalk_che_icons_bg.jpg?w=1024\" data-object-fit=\"cover\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim-0 has-background-dim\" style=\"background-color:#1c1d3e\"><\/span><div class=\"wp-block-cover__inner-container has-global-padding is-layout-constrained wp-block-cover-is-layout-constrained\"><div class=\"cover-content-wrapper\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-b68c6776 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-b68c6776 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/chronichandeczema.ca\/fr-ca\/wp-content\/uploads\/sites\/49\/2026\/09\/mod-1.png?w=546\" alt=\"\" class=\"wp-image-412\"><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Chronic hand eczema is associated with dysregulation of inflammatory responses, disruption of the skin barrier, and alterations in the skin microbiome.<sup>7<\/sup><\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-b68c6776 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/chronichandeczema.ca\/fr-ca\/wp-content\/uploads\/sites\/49\/2026\/09\/mod-2.png?w=532\" alt=\"\" class=\"wp-image-411\"><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Its pathogenesis is further complicated because of the potential for overlapping immune pathways, which are driven by JAK-STAT signaling.<sup>2,7<\/sup><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div><\/div>\n\n\n\n\n<figure class=\"wp-block-image alignfull size-large\" style=\"margin-top:var(--wp--preset--spacing--0);margin-bottom:var(--wp--preset--spacing--0)\"><img loading=\"lazy\" decoding=\"async\" height=\"667\" width=\"1024\" src=\"https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/enough-is-enough.jpg?w=1024\" alt=\"\" class=\"wp-image-338\" srcset=\"https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/enough-is-enough.jpg 2048w, https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/enough-is-enough.jpg?resize=300,195 300w, https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/enough-is-enough.jpg?resize=768,500 768w, https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/enough-is-enough.jpg?resize=1024,667 1024w, https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/enough-is-enough.jpg?resize=1536,1001 1536w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<div class=\"wp-block-group alignfull has-white-color has-primary-background-color has-text-color has-background has-link-color wp-elements-17 has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"margin-top:var(--wp--preset--spacing--0);margin-bottom:var(--wp--preset--spacing--0);padding-top:var(--wp--preset--spacing--xl);padding-bottom:var(--wp--preset--spacing--xl)\">\n<p class=\"is-style-footnote wp-block-paragraph\">CHE=chronic hand eczema; JAK-STAT=Janus kinase signal transducer and activator of transcription.<\/p>\n\n\n\n<div style=\"height:56px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"is-style-footnote wp-block-paragraph\"><strong>References:<\/strong> <strong>1.<\/strong>&nbsp;Apfelbacher C, et al. <em>Acta Derm Venereol<\/em>. 2014;94(2):163-167. doi:10.2340\/00015555-1632 <strong>2.<\/strong>&nbsp;Dubin C, et al. <em>Ther Clin Risk Manag<\/em>. 2020;16:1319-1332. doi:10.2147\/TCRM.S292504 <strong>3.<\/strong>&nbsp;Diepgen TL, et al. <em>J Dtsch Dermatol Ges<\/em>. 2009;7(suppl 3):S1-S16. doi:10.1111\/j.1610-0387.2009.07061.x <strong>4.<\/strong>&nbsp;Thyssen JP, et al. <em>Contact Dermatitis<\/em>. 2022;86(5):357-378. doi:10.1111\/cod.14035 <strong>5.<\/strong>&nbsp;Tauber M, et al. <em>J Eur Acad Dermatol Venereol<\/em>. 2024;38(6):997-998. doi:10.1111\/jdv.20023 <strong>6.<\/strong>&nbsp;Agner T, et al. <em>J Eur Acad Dermatol Venereol<\/em>. 2015;29(12):2417-2422. doi:10.1111\/jdv.13308 <strong>7.<\/strong>&nbsp;Lee GR, et al. <em>Dermatol Ther<\/em>. 2019;32(3):e12840. doi:10.1111\/dth.12840<\/p>\n\n\n\n<div style=\"height:78px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>THE CHALLENGE OF DIAGNOSING CHE Patients with chronic hand eczema (CHE) may present with multiple subtypes and each subtype has unique immune signatures1,2 CHE is not just atopic dermatitis (AD) of the hands2 CHE SUBTYPES Chronic hand eczema is often multifactorial, and the relationship between clinical patterns and etiological diagnoses is not a simple one.Mixed [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-no-title","meta":{"_user_content_segmentation__post_segment_selection":[],"_trash_the_other_posts":false,"style_variation":"che-dark","breadcrumbs_enabled":false,"editor_notices":[],"leo_pharma_teaser_title":"","footnotes":""},"content_tag":[],"class_list":["post-144","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>CHE Diagnosis - Hand Eczema<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/chronichandeczema.ca\/en-ca\/diagnosis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CHE Diagnosis - Hand Eczema\" \/>\n<meta property=\"og:description\" content=\"THE CHALLENGE OF DIAGNOSING CHE Patients with chronic hand eczema (CHE) may present with multiple subtypes and each subtype has unique immune signatures1,2 CHE is not just atopic dermatitis (AD) of the hands2 CHE SUBTYPES Chronic hand eczema is often multifactorial, and the relationship between clinical patterns and etiological diagnoses is not a simple one.Mixed [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/chronichandeczema.ca\/en-ca\/diagnosis\/\" \/>\n<meta property=\"og:site_name\" content=\"Hand Eczema\" \/>\n<meta property=\"article:modified_time\" content=\"2026-10-03T12:34:07+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/chronichandeczema.ca\/en-ca\/wp-content\/uploads\/sites\/48\/2026\/09\/diagnosis_letterforms-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta 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